Mesothelioma Ongoing Clinical Trials - No Phase Specified

SUNY Upstate Medical University Hospital

We want to compare the features that the pathologist sees, when examining a lung tumor under the microscope, to the way that the tumor appears on the CT scan. Features of the tumor may include abnormal blood vessels and areas in which tumor cells are dying. The samples that are taken during the needle biopsy contain information from one small part of the tumor. We believe that we can show where in the tumor the samples came from, based on the CT scans during the biopsy procedure.

New York, NY: Memorial Sloan-Kettering Cancer Center

The purpose of this study is to see how the brain re-learns to control the larynx in speaking and swallowing when undergoing surgical rehabilitation in the form of either thyroplasty or vocal fold augmentation for unilateral vocal cord paralysis. What is needed is information on how the brain re-learns to control speaking and swallowing so that we can eventually learn how to help patients re-learn faster after their procedure. Functional Magnetic Resonance Imaging (or fMRI) will allow us to image your brain as you speak and swallow. We will produce "brain maps" for speaking, swallowing and hand movements.

New York, NY: Memorial Sloan-Kettering Cancer Center

The purpose of this study is to find out whether a new device can help obtain more accurate CT and PET scans of the lungs and chest tumors and the liver and liver tumors to help in delivering radiation therapy. When we breathe, the amount of air in the lung changes. Lung tumors may also move during breathing. Liver tumors may also move with breathing; as the lungs inflate, the liver can be pushed down. A CT scan (a special type of X-ray) is routinely obtained as part of planning for lung or liver radiation therapy.

Madison, WI: University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

The overall, broad objective of this study is to pilot the BSD technique. The specific purpose of this particular study is to generate pilot data to validate several crucial steps of the BSD technique, in particular steps 1, 2, and 4. Radiation treatments will proceed per standard of care, and will not be modified in any way during this protocol. This study is a non-treatment protocol.

Bethesda, MD: NCI - Center for Cancer Research

Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. This laboratory study is looking at previously collected and stored tissue samples from patients previously enrolled in a completed National Cancer Institute clinical trial.

Houston, TX: M. D. Anderson Cancer Center at University of Texas

Primary Objective: To estimate the accuracy of the pre-operative VRI Quantitative Regional Function results versus the gold standard Quantitative Radionuclide Study of Regional Lung Ventilation and Perfusion pre-operative scan.

Detroit, MI: Barbara Ann Karmanos Cancer Institute

Studying samples of body fluid and blood from patients who have been exposed to asbestos or vermiculite in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

Malvern, PA: Fujirebio Diagnostics, Incorporated

The purpose of this clinical trial is to evaluate the ability of various biomarkers measured in serum and/or pleural fluids to estimate the risk of finding cancer in patients with undiagnosed pleural effusions. An algorithm for prediction of the risk of finding cancer in the patient using an optimal combination of markers will be developed, and patients will be categorized as having a low, moderate, or high risk of finding cancer that might be used to more effectively triage patients.

Bethesda, MD: Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office

Collecting and storing samples of tissue, blood, and urine from patients with cancer to study in the laboratory may help the study of cancer. It may also help doctors identify patients who are eligible for clinical trials. This study is collecting and examining tissue, blood, and urine samples from patients with non-small cell lung cancer, esophageal cancer, or malignant pleural mesothelioma.

Toronto, Ontario, Canada: Princess Margaret Hospital

Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure.