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No phase specified
Research Study of Collection of Gynecological Tumor Specimens
No Phase Specified
Location:
Multiple Locations
Trial Summary:
Objectives:
- Collect gynecological tumor specimens and blood from patients at GOG institutions.
- Provide a repository for long-term storage of these specimens.
Contact Information:
Please see additional information.
For Additional Information, Click Here
Prospective Study of Epigenetic Alterations in Patients With Non-Small Cell Lung Cancer, Esophageal Cancer, Malignant Pleural Mesothelioma, Mediastinal or Chest Wall Neoplasms, or Pulmonary Metastases from Cancers of Non-Thoracic Origin
No Phase Specified
Location:
Bethesda, MD: NCI - Center for Cancer Research
Trial Summary:
Objectives:
- Evaluate patients referred to the Thoracic Oncology Section of the Surgery Branch, NCI in order to identify patients who are suitable candidates for clinical research protocols.
- Obtain biopsies during staging studies of tumor and adjacent normal tissues as well as serum and urine samples from patients with primary aerodigestive tract malignancies to support preclinical research endeavors in the Thoracic Oncology Section.
- Permit standard treatment for patients who are not eligible for investigational therapy on a current Thoracic Oncology protocol, but who present a novel and unique clinical training opportunity, or who manifest a clinical condition that requires immediate intervention to prevent compromise to the patient's well-being.
- Permit long-term follow up of patients with thoracic malignancies, including the collection of tissue and fluids to support preclinical research, particularly to ascertain if gene expression and DNA methylation profiles coincide with response to therapy.
Contact Information:
David Schrump, MD, Protocol chair
Ph: 301-496-2127
Email: .(JavaScript must be enabled to view this email address)
For Additional Information, Click Here
Multiple Biomarkers in Undiagnosed Pleural Effusion
No Phase Specified
Location:
Malvern, PA: Fujirebio Diagnostics, Incorporated
Trial Summary:
The purpose of this clinical trial is to evaluate the ability of various biomarkers measured in serum and/or pleural fluids to estimate the risk of finding cancer in patients with undiagnosed pleural effusions. An algorithm for prediction of the risk of finding cancer in the patient using an optimal combination of markers will be developed, and patients will be categorized as having a low, moderate, or high risk of finding cancer that might be used to more effectively triage patients.
Contact Information:
Elizabeth B Somers, BS
Ph: 610-240-3812
Email: .(JavaScript must be enabled to view this email address)
Craig Miller, BS
Ph: 610-240-3828
Email: .(JavaScript must be enabled to view this email address)
For Additional Information, Click Here
Study of Early Detection of Mesothelioma Biomarkers in Patients With Asbestos and Vermiculite Exposure
No Phase Specified
Location:
Detriot, MI: Barbara Ann Karmanos Cancer Institute
Trial Summary:
Objectives:
- Identify patients with known asbestos exposure at early stages of disease development (i.e., indolent premalignant pleural plaques and fibrosis vs malignant pleural mesothelioma).
- Determine the expression levels of tumor-associated proteins in these patients.
- Analyze samples of serum and pleural effusions obtained from these patients.
- Determine the proteomic profile of samples obtained from these patients.
- Determine the molecular mechanisms associated with the regulation of the extracellular matrix microenvironment proteins (e.g., osteonectin, intelectin, or matrix metalloproteins) involved in disease onset and progression.
Contact Information:
Anil Wali, PhD, Protocol chair
Ph: 313-576-8302; 800-527-6266
Email: .(JavaScript must be enabled to view this email address)
For Additional Information, Click Here
Validation of a Novel Thoracic Neoplasm Radiotherapy Image Guidance Technique: A Pilot Study
No Phase Specified
Location:
Madison, WI: University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Trial Summary:
The overall, broad objective of this study is to pilot the BSD technique. The specific purpose of this particular study is to generate pilot data to validate several crucial steps of the BSD technique, in particular steps 1, 2, and 4. Radiation treatments will proceed per standard of care, and will not be modified in any way during this protocol. This study is a non-treatment protocol.
Contact Information:
Cancer Connect
Ph: 608-622-8922
For Additional Information, Click Here
Improving Functional Outcomes in Patients With Unilateral Vocal Cord Paralysis: Assessment of Adaptation Using Functional Magnetic Resonance Imaging
No Phase Specified
Location:
New York, New York: Memorial Sloan-Kettering Cancer Center
Trial Summary:
The purpose of this study is to see how the brain re-learns to control the larynx in speaking and swallowing when undergoing surgical rehabilitation in the form of either thyroplasty or vocal fold augmentation for unilateral vocal cord paralysis. What is needed is information on how the brain re-learns to control speaking and swallowing so that we can eventually learn how to help patients re-learn faster after their procedure. Functional Magnetic Resonance Imaging (or fMRI) will allow us to image your brain as you speak and swallow. We will produce "brain maps" for speaking, swallowing and hand movements.
Contact Information:
Dennis Kraus, MD
Email: .(JavaScript must be enabled to view this email address)
Ryan Branski, PhD
Email: .(JavaScript must be enabled to view this email address)
For Additional Information, Click Here
Investigating the Improvement in 4D CT Images Using AV Biofeedback
No Phase Specified
Location:
Baltimore, MD: Greenebaum Cancer Center at University of Maryland Medical Center
Trial Summary:
This study will look at how tumors in the chest and abdomen move when you breathe. Your doctors are studying if extra 4D CT scans and instructions on how to breathe can help predict this type of movement and improve the accuracy of radiation treatment. 4D CT scans are approved by the FDA. A 4D CT scan is different from a regular CT because it moves slower and takes more pictures. It takes pictures of the way your body moves when you breathe. This gives doctors more pictures of your body so that they can match your pictures to the way you breathe. In this study, instructions on how to breathe will be visual and audio. Visual instructions will be given to you on a computer screen. You will hear audio instructions through a speaker.
Contact Information:
Rohini George, PhD
Ph: (410) 328-3658
Email: .(JavaScript must be enabled to view this email address)
Ritesh S Kataria, MS
Ph: 410-328-8018
Email: .(JavaScript must be enabled to view this email address)
For Additional Information, Click Here
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